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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TOP3A
All Species:
21.52
Human Site:
S395
Identified Species:
31.56
UniProt:
Q13472
Number Species:
15
Phosphosite Substitution
Charge Score:
-0.4
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q13472
NP_004609.1
1001
112372
S395
R
W
G
A
F
A
Q
S
I
L
E
R
G
G
P
Chimpanzee
Pan troglodytes
XP_511323
1001
112378
S395
R
W
G
A
F
A
Q
S
I
L
E
R
G
G
P
Rhesus Macaque
Macaca mulatta
XP_001095437
1001
112278
S395
R
W
G
A
F
A
Q
S
I
L
E
R
G
G
P
Dog
Lupus familis
XP_546656
989
110956
S395
R
W
G
A
F
A
Q
S
I
L
E
R
G
G
P
Cat
Felis silvestris
Mouse
Mus musculus
O70157
1003
112340
T395
H
W
G
A
F
A
Q
T
I
L
E
R
G
G
P
Rat
Rattus norvegicus
XP_002742497
1001
111922
T395
X
W
G
A
F
A
Q
T
F
X
S
E
R
P
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510142
1042
116269
R438
H
W
G
D
F
A
Q
R
I
L
D
R
G
G
P
Chicken
Gallus gallus
NP_001025807
1020
114626
R397
N
W
G
A
F
A
Q
R
I
L
D
Q
G
G
P
Frog
Xenopus laevis
NP_001085699
1022
114003
R400
Q
W
G
G
F
A
Q
R
I
L
E
R
G
G
P
Zebra Danio
Brachydanio rerio
XP_688695
998
112490
R393
E
W
G
N
F
A
Q
R
I
L
E
S
G
G
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9NG98
1250
136119
R389
D
W
G
A
F
A
Q
R
V
I
E
W
G
P
N
Honey Bee
Apis mellifera
XP_394050
958
109977
Q363
A
W
G
N
F
A
Q
Q
L
L
E
K
G
V
N
Nematode Worm
Caenorhab. elegans
O61660
759
85420
S208
L
L
G
Q
N
D
T
S
Q
V
I
S
Y
G
S
Sea Urchin
Strong. purpuratus
XP_782119
679
77025
N128
D
C
D
R
E
G
E
N
I
G
Y
E
V
I
D
Poplar Tree
Populus trichocarpa
XP_002307047
910
102138
V353
R
T
D
L
H
T
I
V
Q
E
H
Q
E
H
P
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_201197
926
103389
R375
A
W
G
S
Y
A
Q
R
L
L
E
P
E
G
G
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99
94.9
87.7
N.A.
86.8
83.8
N.A.
72.8
73
70.9
66.5
N.A.
41.2
46.8
38.5
47
Protein Similarity:
100
99.6
97
91.1
N.A.
91.5
88.9
N.A.
80.5
82.9
81.8
80.3
N.A.
53.7
63.7
50.8
57
P-Site Identity:
100
100
100
100
N.A.
86.6
46.6
N.A.
73.3
73.3
80
73.3
N.A.
53.3
53.3
20
6.6
P-Site Similarity:
100
100
100
100
N.A.
93.3
53.3
N.A.
80
86.6
86.6
73.3
N.A.
66.6
66.6
26.6
20
Percent
Protein Identity:
40
N.A.
N.A.
38.8
N.A.
N.A.
Protein Similarity:
56.3
N.A.
N.A.
54.5
N.A.
N.A.
P-Site Identity:
13.3
N.A.
N.A.
46.6
N.A.
N.A.
P-Site Similarity:
20
N.A.
N.A.
66.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
13
0
0
50
0
82
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
7
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
13
0
13
7
0
7
0
0
0
0
13
0
0
0
7
% D
% Glu:
7
0
0
0
7
0
7
0
0
7
63
13
13
0
0
% E
% Phe:
0
0
0
0
75
0
0
0
7
0
0
0
0
0
0
% F
% Gly:
0
0
88
7
0
7
0
0
0
7
0
0
69
69
7
% G
% His:
13
0
0
0
7
0
0
0
0
0
7
0
0
7
0
% H
% Ile:
0
0
0
0
0
0
7
0
63
7
7
0
0
7
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
7
0
0
0
% K
% Leu:
7
7
0
7
0
0
0
0
13
69
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
7
0
0
13
7
0
0
7
0
0
0
0
0
0
13
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
7
0
13
69
% P
% Gln:
7
0
0
7
0
0
82
7
13
0
0
13
0
0
0
% Q
% Arg:
32
0
0
7
0
0
0
38
0
0
0
44
7
0
0
% R
% Ser:
0
0
0
7
0
0
0
32
0
0
7
13
0
0
7
% S
% Thr:
0
7
0
0
0
7
7
13
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
7
7
7
0
0
7
7
0
% V
% Trp:
0
82
0
0
0
0
0
0
0
0
0
7
0
0
0
% W
% Tyr:
0
0
0
0
7
0
0
0
0
0
7
0
7
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _